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Protein–Bacteria Association Atlas

Systematically integrated associations between gut microbiota and serum proteome, and between serum proteins and the Frailty Index, across discovery and multiple independent validation cohorts.

36 microbiome–protein associations · 47 FI–protein associations · Multiple validation cohorts

Microbiome–Protein data (.xlsx) FI–Protein data (.xlsx)

Microbiome–Protein Associations

Discovery and validation cohorts · 36 associations · 32 taxa · 31 proteins

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Bacteria–Protein Association Circos Plot

Circos plot of bacteria–protein associations

Left arc: serum proteins · Right arc: gut bacteria colored by phylum · Red links: positive associations (r > 0) · Green links: negative associations (r < 0) · Click to enlarge

Discovery vs External Validation

Discovery vs Internal Validation

Selected Association — Effect Estimates (95% CI)

Click any data point above to view per-cohort effect estimates.

Frailty Index–Protein Associations

Discovery + internal + external validation · 47 proteins · Genetic / microbiome / diet evidence

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Discovery vs External Validation

Discovery vs Internal Validation

Validation Evidence

β Coefficients — Discovery Cohort

Selected Protein — Effect Estimates (95% CI)

Click any data point above to view per-cohort effect estimates.